PENGARUH EFEK SAMPING PENGGUNAAN OBAT OFF LABEL TERHADAP KUALITAS HIDUP PASIEN LUPUS DI RSUD ULIN BANJARMASIN
Abstract
Lupus Eritematosus Sistemik merupakan penyakit inflamasi autoimun kronis yang belum jelas penyebabnya, memiliki variasi gambaran klinis yang luas dan tampilan perjalanan penyakit yang beragam. Penggunaan obat-obatan off label seperti kortikosteroid untuk pengobatan SLE dapat mengakibatkan potensi efek samping yang besar terhadap pasien Lupus. Penelitian ini bertujuan untuk mengetahui pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus, mengetahui tingkat efek samping penggunaan obat-obatan off label serta mengetahui tingkat kualitas hidup pasien lupus. Penelitian ini dilakukan menggunakan metode potong lintang (cross sectional) dengan cara survey menggunakan intrumen Algoritma Naranjo dan instrumen kuesioner Quality of Life (WHOQOL)–BREF dengan responden pada penelitian ini berjumlah 28 responden. Berdasarkan hasil penelitian didapatkan hasil bahwa efek samping penggunaan obat-obatan off label tidak mempunyai hubungan yang signifikan terhadap kualitas hidup pada pasien lupus atau dalam kata lain tidak ada pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus. Data penelitian menunjukkan nilai r hitung (pearson correlations) adalah -0,016 dan nilai Sig (2-tailed) adalah 0,936. Hasil analisis pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pada pasien lupus sangat jelas menggambarkan bahwa tidak ada hubungan signifikan antara efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus, namun pada korelasi ini terdapat hubungan yang tidak searah, dimana apabila nilai efek samping yang dialami responden tinggi maka nilai kualitas hidup responden justru rendah. Sebaliknya apabila nilai efek samping yang dialami responden rendah maka nilai kualitas hidup responden akan tinggi.
Kata Kunci: Lupus, Off Label, Efek Samping, Kualitas Hidup, Autoimun.
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Systemic lupus erythematosus is a chronic autoimmune inflammatory disease whose cause is unclear, has a wide variety of clinical features and diverse appearance of the disease course. The use of off label drugs such as corticosteroids for the treatment of SLE can have the potential for large side effects on Lupus patients. This study aims to determine the effect of side effects of off label drug use on the quality of life of lupus patients, determine the level of side effects of using off label drugs and determine the level of quality of life of lupus patients. This research was conducted using a cross sectional method by surveying using the Naranjo Algorithm instrument and the Quality of Life (WHOQOL) -BREF questionnaire instrument with the respondents in this study totaling 28 respondents. Based on the results of the study found that the side effects of using off label drugs do not have a significant relationship to the quality of life in lupus patients or in other words there is no effect of the side effects of using off label drugs on the quality of life of lupus patients. The research data shows the value of r count (Pearson correlations) is -0.016 and the value of Sig (2-tailed) is 0.936. The results of the analysis of the effect of side effects of off label use on quality of life in lupus patients clearly illustrates that there is no significant relationship between the side effects of using off label drugs on the quality of life of lupus patients, but in this correlation there is a non-directional relationship, where if the value of side effects experienced by respondents is high then the quality of life of respondents is actually low. Conversely, if the value of side effects experienced by respondents is low then the quality of life of respondents will be high.
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Keywords: Lupus, Off Label, Side Effects, Quality of Life, Autoimmune.
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