PENGARUH EFEK SAMPING PENGGUNAAN OBAT OFF LABEL TERHADAP KUALITAS HIDUP PASIEN LUPUS DI RSUD ULIN BANJARMASIN

Iwan Yuwindry, Noval Noval

Abstract


Lupus Eritematosus Sistemik merupakan penyakit inflamasi autoimun kronis yang belum jelas penyebabnya, memiliki variasi gambaran klinis yang luas dan tampilan perjalanan penyakit yang beragam. Penggunaan obat-obatan off label seperti kortikosteroid untuk pengobatan SLE dapat mengakibatkan potensi efek samping yang besar terhadap pasien Lupus. Penelitian ini bertujuan untuk mengetahui pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus, mengetahui tingkat efek samping penggunaan obat-obatan off label serta mengetahui tingkat kualitas hidup pasien lupus. Penelitian ini dilakukan menggunakan metode potong lintang (cross sectional) dengan cara survey menggunakan intrumen Algoritma Naranjo dan instrumen kuesioner Quality of Life (WHOQOL)–BREF dengan responden pada penelitian ini berjumlah 28 responden. Berdasarkan hasil penelitian didapatkan hasil bahwa efek samping penggunaan obat-obatan off label tidak mempunyai hubungan yang signifikan terhadap kualitas hidup pada pasien lupus atau dalam kata lain tidak ada pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus. Data penelitian menunjukkan nilai r hitung (pearson correlations) adalah -0,016 dan nilai Sig (2-tailed) adalah 0,936. Hasil analisis pengaruh efek samping penggunaan obat-obatan off label terhadap kualitas hidup pada pasien lupus sangat jelas menggambarkan bahwa tidak ada hubungan signifikan antara efek samping penggunaan obat-obatan off label terhadap kualitas hidup pasien lupus, namun pada korelasi ini terdapat hubungan yang tidak searah, dimana apabila nilai efek samping yang dialami responden tinggi maka nilai kualitas hidup responden justru rendah. Sebaliknya apabila nilai efek samping yang dialami responden rendah maka nilai kualitas hidup responden akan tinggi.

Kata Kunci: Lupus, Off Label, Efek Samping, Kualitas Hidup, Autoimun.

 

Systemic lupus erythematosus is a chronic autoimmune inflammatory disease whose cause is unclear, has a wide variety of clinical features and diverse appearance of the disease course. The use of off label drugs such as corticosteroids for the treatment of SLE can have the potential for large side effects on Lupus patients. This study aims to determine the effect of side effects of off label drug use on the quality of life of lupus patients, determine the level of side effects of using off label drugs and determine the level of quality of life of lupus patients. This research was conducted using a cross sectional method by surveying using the Naranjo Algorithm instrument and the Quality of Life (WHOQOL) -BREF questionnaire instrument with the respondents in this study totaling 28 respondents. Based on the results of the study found that the side effects of using off label drugs do not have a significant relationship to the quality of life in lupus patients or in other words there is no effect of the side effects of using off label drugs on the quality of life of lupus patients. The research data shows the value of r count (Pearson correlations) is -0.016 and the value of Sig (2-tailed) is 0.936. The results of the analysis of the effect of side effects of off label use on quality of life in lupus patients clearly illustrates that there is no significant relationship between the side effects of using off label drugs on the quality of life of lupus patients, but in this correlation there is a non-directional relationship, where if the value of side effects experienced by respondents is high then the quality of life of respondents is actually low. Conversely, if the value of side effects experienced by respondents is low then the quality of life of respondents will be high.

 

Keywords: Lupus, Off Label, Side Effects, Quality of Life, Autoimmune.


Full Text:

FULL TEXT PDF

References


Alarcon. 2001. Systemic lupus erythematosus in three ethnic groups. IX. Differences in damage accrual. The University of Alabama. Birmingham: NCBI.

Aringer. 2012. Innate immune processes in lupus erythematosus. Division of Rheumatology. Department of Medicine III, University Clinical Center Carl Gustav Carus. Dresden: NCBI.

Dworkin. 2010. Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update. Department of Anesthesiology, University of Rochester School of Medicine and Dentistry. New York: NCBI.

Isbagio H. 2009. Lupus Eritematosus Sistemik Dalam: Sudoyo AW, Setiyohadi B, Alwi I, et al, editor. Ilmu Penyakit Dalam Jilid III. Edisi kelima. Jakarta: Interna Publishing, 2565-2579.

Jennifer. 2010. Buku Ajar Patofisiologi. Jakarta: EGC.

Lin. 2006. The Effect of Brand Image and Product Knowledge on Purchase Intention Moderated by Price Discount. Journal of International Management Studies.

Lopez SJ, Snyder CR, Pedrotti JT. 2003. Hope: Many Definitions, Many Measures. Dalam S. J. Lopez & C. R. Snyder (Eds). Positive Psychological Assessment, A Handbook of Models and Measures. Washington, DC, US: American Psychological Association 91-106.

Prince M. 2010. Histochemical and biochemical studies of parasite host interaction of Cassytha filiformis Linn and Zisyphus jujube Lamk. Current Science.

Priyanto, Duwi. 2010. Teknik Mudah dan Cepat Melakukan Analisis Data Penelitian dengan SPSS. Yogyakarta: Gava Media.

Qureshi. 2011. Effect of silicon level on growth and yield of wheat in silty loam soil. Pak J Bot.

Santoso. 2005. Metodologi Penelitian Kuantitatf dan Kualitatif. Jakarta: Prestasi Pustaka.

Schatz. 2015. Managing asthma exacerbations in the emergency departement. Proc Am Thorac.

Shah. 2007. Pharmacognosy Review. Gujarat, India.

Stafford, L. 2008. Maintenance Strategies and romantic relationship type, gender and relational characteristics. Journal of Social and Personal Relationships.

Sugiyono. 2002. Metode Penelitian Administrasi. Bandung: CV Alfabeta.


Refbacks

  • There are currently no refbacks.