H Hemoglobin Levels of Wistar Rats After Saluang Fish (Rasbora Spp) Powder Administration
Keywords:
Anemia, hemoglobin, Saluang Fish Powder, Wistar RatsAbstract
It is estimated that 40% of children aged between 6-59 months experience anemia worldwide. In Indonesia prevalence of anemia in children under five reaches 38.5%, and 26.8% in children ages 5-14 years. Food first consumed by baby tends to support the absorption substance iron that causes Iron Deficiency Anemia (IDA). Saluang fish powder is a material food proven locally and contains high in protein, calcium, and substances iron. Research objectives : This study was to determine hemoglobin levels in Wistar Rats after being given a dose of Saluang fish powder. The method used is true experimental with post-test only design in Wistar Rats for 16 weeks in the Laboratory of Pharmacology, Universitas Muhammadiyah Palangkaraya. Control group divided into positive control group and negative control group. Whereas treatment group divided into of three groups which each given dose differently, low dose (0,36 g/ 200 g BW), moderate dose (0,54 g/ 200 gr BW), high dose (0,72 g/ 200 g BW) for 2 times a day intraperotoneal and standar feed ad libitum . The results show the average levels of hemoglobin group negative control was 19.617 mg/dL, and the group control positive 20.28 mg/dL. The average level of hemoglobin in the group in each treatment is that given dose light (19.65 grams/ dL), dose moderate (18.96 mg/dL), and dose high (20.33 mg/ dL). Statistical test results show there is no difference in average levels of hemoglobin in a low dose group (p-value=0.63), moderate dose group (p-value=0.77), and high dose group (p-value=0.189) with hemoglobin levels in the negative control group. However, there is a difference in average levels of hemoglobin in the treatment group(p-value=0.000) with average levels
References
Anonim, 2019. Kementrian Koordinator Bidang Pembangunan Manusia Dan Kebudayaan RI.
Ari Y. 2014. Pengembangan Potensi Ikan Seluang (Rasbora Spp.) Sebagai Sumber Nutrisi Yang Meningkatkan Memori Spasial Dan Ekspresi Peroxisome Proliferator Activated Receptor (PPAR) Otak Studi Eksperimental Pada Tikus Rattus Norvegicus. Accessed October 31, 2023. Https://Www.Semanticscholar.Org/Paper/Pengembangan-Potensi-Ikan-Seluang-(Rasbora-Spp.)-Ari/77e67e18d2851c9cec4466a29e2dd8f140a509e6
Aurora WID. 2021. Efek Pemberian Zat Besi Tambahan Pada Anak. Jambi Medical Journal “Jurnal Kedokteran Dan Kesehatan.” No 9(2):199-203. Doi:10.22437/Jmj.V9i1.13122
Babitt JL, Lin HY. 2012. Mechanisms Of Anemia In CKD. Journal Of The American Society Of Nephrology : JASN. Number 23(10):1631. Doi:10.1681/ASN.2011111078
Consortia. 1995. The British Nutrition Foundation. Iron And Anaemia. In: Iron: Nutritional And Physiological Significance The Report Of The British Nutrition Foundation’s Task Force. Springer Netherlands; Page 42-49. Doi:10.1007/978-94-011-0585-9_7
Dallman PR, Siimes MA, Stekel A. 1980. Iron Deficiency In Infancy And Childhood. Am J Clin Nutr. 1980;33(1):86-118. Doi:10.1093/Ajcn/33.1.86
Dewi PFA, Widarti IGAA, Sukraniti DP. 2018. Pengetahuan Ibu Tentang Ikan Dan Pola Konsumsi Ikan Pada Balita Di Desa Kedonganan Kabupaten Badung. Jurnal Ilmu Gizi : Journal Of Nutrition Science; 7(1):17-20. Doi:10.33992/Jig.V7i1.213
Diana R, Khomsan A, Anwar F, Christianti DF, Kusuma R, Rachmayanti RD. 2019. Dietary Quantity And Diversity Among Anemic Pregnant Women In Madura Island, Indonesia. J Nutr Metab; Number :2647230. Doi:10.1155/2019/2647230
Gillespie S. 1998. Major Issues In The Control Of Iron Deficiency. New York : USA
Gupta PM, Perrine CG, Mei Z, Scanlon KS. 2016. Iron, Anemia, And Iron Deficiency Anemia Among Young Children In The United States. Nutrients. 2016;8(6):330. Doi:10.3390/Nu8060330
Harahap LAH, Siregar SMF, Mulyani I. 2023. The Relationship Between Protein Consumption And Hemoglobin Levels Of Female Students Of Universitas Teuku Umar. Journal Of Nutrition Science. Number 4(1):22-25. Doi:10.35308/Jns.V4i1.7499
Hesty H. 2020. Rekayasa Proses Pengolahan Ikan Seluang (Rasbora Sp) Sebagai Nutraceutical. Published Online June 15, 2020. Accessed October 21, 2023. Https://Repo-Dosen.Ulm.Ac.Id//Handle/123456789/9937
Lestari RM, Triawanti T, Yunanto A. 2016. Efek Pemberian Ikan Saluang (Rasbora Spp.) Terhadap Kadar Kalsium Tulangtikus Putih (Rattus Norvegicus) Malnutrisi. Berkala Kedokteran. 12(1):69-76. Doi:10.20527/Jbk.V12i1.358
Lönnerdal B. 2010. Calcium And Iron Absorption--Mechanisms And Public Health Relevance. Int J Vitam Nutr Res.Number 80(4-5):293-299. Doi:10.1024/0300-9831/A000036
Miranda M, Olivares M, Brito A, Pizarro F. 2014. Reducing Iron Deficiency Anemia In Bolivian School Children: Calcium And Iron Combined Versus Iron Supplementation Alone. Nutrition; 30(7):771-775. Doi:10.1016/J.Nut.2013.12.008
Miller JL. 2013. Iron Deficiency Anemia: A Common And Curable Disease. Cold Spring Harb Perspect Med. Number 3(7):A011866. Doi:10.1101/Cshperspect.A011866
Mohammed SH, Larijani B, Esmaillzadeh A. 2019. Concurrent Anemia And Stunting In Young Children: Prevalence, Dietary And Non-Dietary Associated Factors. Nutrition Journal. Number 18(1):10. Doi:10.1186/S12937-019-0436-4
Monsen ER, Cook JD. Food Iron Absorption In Human Subjects. IV. The Effects Of Calcium And Phosphate Salts On The Absorption Of Nonheme Iron. Am J Clin Nutr. 1976;29(10):1142-1148. Doi:10.1093/Ajcn/29.10.1142
Nasution E. 2004. Efek Suplementasi Zinc Dan Besi Pada Pertumbuhan Anak. Published Online 2004.
Nurhalina N, Purbayanti D, Ardina R, Fitriyanto M. 2020. Pengaruh Pemberian MP-ASI Terhadap Tingkat Morbiditas Anak Di Indonesia (Analisis Data SDKI Tahun 2017): The Influence Of Complementary Food Of Breast Milk To Children Morbidity Level In Indonesia (Data Analysis Of IDHS In 2017). Jurnal Surya Medika (JSM); 5(2):160-168. Doi:10.33084/Jsm.V5i2.1324
Pratiwi R, Widari D. 2018. Hubungan Konsumsi Sumber Pangan Enhancer Dan Inhibitor Zat Besi Dengan Kejadian Anemia Pada Ibu Hamil. Amerta Nutrition. Number 2(3):283-291. Doi:10.20473/Amnt.V2i3.2018.283-291
Rieny EG, Nugraheni SA, Kartini A. 2021. Peran Kalsium Dan Vitamin C Dalam Absorpsi Zat Besi Dan Kaitannya Dengan Kadar Hemoglobin Ibu Hamil: Sebuah Tinjauan Sistematis. Media Kesehatan Masyarakat Indonesia. Volume 20(6):423-432. doi:10.14710/mkmi.20.6.423-432
Riswanda J. Hubungan Asupan Zat Besi Dan Inhibitornya Sebagai Prediktor Kadar Hemoglobin Ibu Hamil Di Kabupaten Muara Enim. Jurnal Biota. 2017;3(2):83-89. Doi:10.19109/Biota.V3i2.1319
Smith JB, Mangkoewidjojo S. 1988. Pemeliharaan, Pembiakan Dan Penggunaan Hewan Percobaan Di Daerah Tropis. UI-Press. Accessed October 31, 2023. Https://Lib.Ui.Ac.Id
Storz JF. 2018. Hemoglobin: Insights Into Protein Structure, Function, And Evolution. Oxford University Press.
Toaha A, Asad S, Hadju V, Bahar B. 2015. Factors Related To Anemia In Pregnant Women Of Dayak Kenyah Tribe At Kutai Kartanegara Regency, East Kalimantan Province. Pakistan Journal Of Nutrition. Volume 14:637-641. Doi:10.3923/Pjn.2015.637.641
Tumongka S, Suryani N, Syainah E, Yudistira S. 2022. Analisis Kadar Kalsium, Zat Besi Dan Daya Terima Cookies Ikan Seluang (Rasbora Sp) Kacang Tunggak (Vigna Unguiculata) Sebagai Makanan Selingan Anemia Remaja Perempuan. Jurnal Kesehatan Indonesia. 12(3):140-147.
Turner J, Parsi M, Badireddy M. 2023. Anemia. In: Statpearls [Internet]. Statpearls Publishing; 2023. Accessed October 21, 2023. Https://Www.Ncbi.Nlm.Nih.Gov/Books/NBK499994/
Von Drygalski A, Adamson JW. 2013. Iron Metabolism In Man. Journal Of Parenteral And Enteral Nutrition. Number 37(5):599-606. Doi:10.1177/0148607112459648
WHO. 2023. Anaemia. Published May 1, 2023. Accessed October 25, 2023. /Https://Www.Who.Int/News-Room/Fact-Sheets/Detail/Anaemia
Yunanto A, Sanyoto DD, Noor MS. 2020. Pengembangan Potensi Ikan Seluang (Rasbora Spp) Sebagai Sumber Nutrisi Yang Meningkatkan Memori Spasial Dan Ekspresi Peroxisome Proliferator Activated Receptor (PPAR) Otak Studi Eksperimental Pada Tikus Rattus Norvegicus. Universitas Lambung Mangkurat. Accessed October 31, 2023. Https://Repo-Dosen.Ulm.Ac.Id//Handle/123456789/8308
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