L LIMPASU (Baccarea lanceolata (Miq.) Müll.Arg.) AS A CYP2C9 INHIBITOR FUNCTIONING IN XENOBIOTIC METABOLISM
english
Keywords:
limpasu, CYP2C9, dockingAbstract
Hepatotoxic is incident damage liver caused by substances poisonous. Poisonous substance That can caused by drugs medicine, poison industry, alcohol, and fungi poisonous. So that objective study This is CYP2C inhibitor screening 9 of compounds contained from B. lanceolata. Method used in study This is docking using PLANTS software and the compounds contained contained in B. lanceolata obtained of KNAPSACK, research This started with redocking ligand against CYP2C9, and obtained docking coordinates used for docking the compounds contained from B. lanceolata . Docking results obtained is as following Melatonin: -72.0859; Epidihydrotutin : -67.2656; Sapidolide A: -68.1767; 6'-O-Vanilloylisotachioside : -81.4806; 6'-O-Vanilloyltachioside: -92.3659. Research conclusions This is compounds contained from Spleen Two potential compounds were obtained as a CYP2C9 inhibitor 6'-O-Vanilloylisotachioside and 6'-O-Vanilloyltachioside.
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