ANTIDIARRHEAL ACTIVITY OF ETHANOL EXTRACT OF LABAN BARK (VITEX PUBESCENS VAHL) IN MICE (MUS MUSCULUS).

Authors

  • Siti Nadila Rahmah Universitas Sari Mulia
  • Dyan Fitri Nugraha
  • Bgaus Rahmat Santoso

Keywords:

Factors, Self Care Management, Type 2 Diabetes Mellitus.

Abstract

Diarrhea is the second leading cause of death in children under 5 years in the world with a percentage of 16%. People especially in Kalimantan often use natural ingredients-based diarrhea treatment, one of which is laban bark, so researchers want to know the antidiarrheal activity of laban bark for diarrhea treatment. The goal is to determine the antidiarrheal effect of Laban bark extract on mice induced by Oleum ricini and the optimum concentration that can have an antidiarrheal effect. The methods is research design is quantitative experimental with a true experimental research design and with a pretest-posttest design with control group design. The results showed that there was a decrease in the frequency of defecation and an increase in stool consistency at doses of 250 mg/kgBW, 500 mg/kgBW, and 750 mg/kgBW. There is a difference between the parameters of the frequency of defecation and stool consistency with a significance value of <0.05. Laban bark ethanol extract Dosage of 250 mg/KgBW is better than doses of 500 mg/kgBW, and 750 mg/kgBW. The Conclusion is laban bark ethanol extract can provide antidiarrheal activity at doses of 250 mg/kgBW, 500 mg/kgBW, and 750 mg/kgBW based on the parameters of frequency of defecation and stool consistency. Doses of 250 mgkgBW have the best effect, because doses of 250 mg/kgBW and 5oo mg/kgBW are suspected to be toxic

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Published

2021-10-21