THE EFFECT OF VARIATIONS IN THE CONCENTRATION OF THE TRIETHANOLAMINE AND STEARIC ACID ON THE PHYSICAL STABILITY OF THE NANOPARTICLE CREAM OF KAPUL SEED EXTRACT (Baccaurea macrocarpa)

Authors

  • Karien Fitria Armilawati Sari Mulia University
  • Noval Noval Sari Mulia University
  • Muhammad Zulfadhilah Sari Mulia University

Keywords:

cream, nanoparticle, emulsifier, triethanolamine, stearic acid

Abstract

Nanoparticle cream are made to deliver the active ingredients more precisely to the target with minimal side effect. Preparation of kapul seed extract cream required the addition of emulsifier as it can affect the quality and stability of the cream. One of the emulsifiers used is triethanolamine and stearic acid with a certain concentration. This study aimed to determine the effect of variations in the concentration of triethanolamine and stearic acid on physical properties and determine the physical stability of cream preparations. The method used for this study is experimental with a true-experimental design. The results will be analyzed using one way ANOVA statistical test. The results showed that the nanoparticle cream of kapul seed extract with various concentrations of triethanolamine and stearic acid had no effect on the organoleptic and homogeneity tests, but did affect the viscosity, pH, stickiness and spreadability of the cream. The formula for nanoparticle cream of kapul seed extract that complies with the requirements is formula 1 in combination with 2 gram of triethanolamine and 4 gram of stearic acid for pH and spreadability, formula 3 with a combination of 3 gram triethanolamine and 10 gram stearic acid and formula 4 with combination of 4 gram triethanolamine and 12 gram stearic acid for adhesivity.

References

Bakar, M. F., Ahmad, N. E., Karim, F. A., & Saib, S. (2014). Phytochemicals and Antioxidative Properties of Borneo Indigenous Liposu (Baccaurea lanceolata) and Tampoi (Baccaurea macrocarpa) Fruits. Antiokxidants, 516-525. doi:10.3390/antiox3030516
Baskara, I., Suhendra, L., & Wrasiati, L. (2020). Pengaruh Suhu Pencampuran dan Lama Pengadukan terhadap Karakteristik Sediaan Krim. Jurnal Rekayasa dan Manajemen Agroindustri, 8(2), 200-209. doi:10.24843/JRMA.2020.v08.i02.p05
Chomariyah, N., Darsono, F., & WIjaya, S. (2019). Optimasi Sediaan Pelembab Ekstrak Kering Kulit Buah Manggis (Garcinia mangostana L.) dengan Kombinasi Asam Stearat dan Trietanolamin sebagai Emulgator. Journal of Pharmacy Science and Practice, Vol. 6 No. 1, 16-23.
Depkes, R. (1979). Farmakope Indonesia edisi III. Jakarta: Departemen Kesehatan Republik Indonesia.
Dina, A., Sugihartini, N., & Pramono, S. (2017). Optimasi komposisi emulgator dalam formulasi krim fraksi etil asetat ekstrak kulit batang nangka (Artocarpus heterophyllus Lamk).
Elmitra, M. (2017). Dasar-Dasar Farmasetika dan Sediaan Semi Solid. Yogyakarta: Deepublish.
Harliantika, Y. (2021). Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilaria malacensis Lamk.) dengan Kombinasi Basis Karbopol 940 dan HPMC K4M. Journal of Pharmacy and Science, 6(1), 37-46.
Haryono, I. A., Noval, N., & Nugraha, B. (2021). Formulasi Buah Tampoi (Baccaurea macrocarpa) dalam Sediaan Masker Gel sebagai Antiaging. Jurnal Surya Medika (JSM), 6(2), 102-110.
Kreuter, J. (2014). Colloidal Drug Delivery Systems (Vol. 66). New York: CRC Press.
Kumalasari, E., Mardiah, A., & Sari, A. (2020). Formulasi Sediaan Krim Ekstrak Daun Bawang Dayak (Eleutherine Palminora (L) Merr) Dengan Basis Krim Tipe A/M dan Basis Krim Tipe M/A. Alfamedis, 1(1), 23-33. Retrieved from alfamedis.com/index.php/alfamedis/article/view/2
Latif, A., Sugihartini, N., & Guntarti, A. (2020). Sifat Fisik Krim Tipe A/M Dengan Variasi Konsentrasi Ekstrak Etanol Daun Kelor Moringa Oliefera Menggunakan Emulgator Tween 80 dan Span 80. Media Farmasi, 9-17. doi:10.32382/mf.v16i1.1408
Martin, A., & Swarbrick, J. (1993). Farmasi Fisik: Dasar-dasar kimia fisik dalam ilmu farmasetik. Jakarta: UI Press.
Noval, N., & Malahayati, S. (2021). Teknologi penghantaran obat terkendali (H. Aulia (ed.); Pertama). CV. Pena Persada.
Rismana, E., Kusumaningrum, S., Bunga, O., Nizar, & Marhamah. (2014). Pengujian aktivitas antiacne nanopartikel kitosan – ekstrak kulit buah manggis (Garcinia Mangostana). Media Litbangkes. Retrieved from http://ejournal.litbang.depkes.go.id/index.php/MPK/article/view/3483
Salsabila, N., Indratmoko, S., & N.L.O, A. T. (2020). Pengembangan Hand & Body Lotion Nanopartikel Kitosan Dan Spirulina SP Sebagai Antioksidan. Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS, 11-20.
Saryanti, D., Nugraheni, D., Astuti, N. S., & Pertiwi, N. I. (2019). Optimasi Karbopol dan HPMC dalam Formulasi Gel Antijerawat Nanopartikel Ekstrak Daun Sirih (Piper betle Linn). Jurnal Ulmiah Manuntung, 5 (2). doi:10.51352/jim.v5i2.293
Sharon, N., Anam, S., & Yuliet. (2013). Formulasi Krim Antioksidan Ekstrak Etanol Bawang Hutan (Eleutherine palmifolia L. Merr). Natural Science: Journal of Science and Technology, 2 (3). doi:10.22487/25411969.2013.v2.i3.1872
Tirtana, E., Idiawati, N., Warsidah, & Jayuska, A. (2013). Analisa Proksimat, Uji Fitokimia Dan Aktivitas Antioksidan pada Buah Tampoi (Baccaurea macrocarpa). Jurnal Kimia Khaulistiwa, 2 (1), 42-45. Retrieved from https://jurnal.untan.ac.id/index.php/jkkmipa/article/view/1761
Wulandari, D. (2019). Optimasi dan Karakteristik Nanopartikel Perak dari Ekstrak Air Bunga Telang. Skripsi.
Yusuf, N. A., Hardianti, B., & Dewi, I. (2018). Formulasi dan evaluasi krim liofilisat buah tomat (Solanum Lycopersium L.) sebagai peningkat kelembaban pada kulit. JCPS (Journal of Current Pharmaceutical Sciences, 2(1), 118-124. Retrieved from Journal.umbjm.ac.id/index.php/jcps/article/view/160

Downloads

Published

2021-10-22