ANTIBACTERIAL ACTIVITY OF Kumis Kucing LEAF EXTRACT (Orthosiphon Stamineus) AGAINST Propionibacterium acnes BACTERIA

Authors

  • Fiytary Noor Madani Sari Mulia University
  • Putri V. Darsono
  • Melviani Melviani

Keywords:

Antibacterial, Kumis Kucing Leaf (Orthosiphon stamineus), Propionibacterium acnes

Abstract

Acne is a skin disease that often affects teenagers to adults and a skin disease that almost happens to everyone. The main bacteria that causes acne is Propionibacterium acnes. Previous research stated that the extract of the Kumis Kucing leaf contains secondary metabolites have antibacterial inhibition is flavonoids, alkaloids, saponins, steroids and terpenoids. This study to determine the antibacterial activity extract of Kumis Kucing leaves against Propionibacterium acnes bacteria through MIC and MBC testing. The methods used in this study is a true experimental method with post test only with control group design. Propionibacterium acnes bacteria as research subjects were given 5 treatment groups is extracts of Kumis Kucing (Orthosiphon Stamineus) leaves with concentrations of 50%, 75%, and 100%, as well as positive control clindamycin and negative control DMSO 10%. The method in this study uses the disc diffusion method and liquid dilution. Antibacterial testing on the disc diffusion method obtained extracts of Kumis Kucing (Orthosiphon stamineus) leaves is the inhibition zone of 7.46 mm while the dilution method contained MIC at a concentration of 50% (0,5 g/10 ml), while the MBC was not obtained. The results of the statistical test Kruskal Wallis 0,018 and Mann Whitney 0,025 showed a p value <0,05, indicating that there was a significant difference between all treatments and between two variations in the concentration of Kumis Kucing (Orthosiphon stamineus) leaf extract against Propionibacterium acnes. The Conclusion is extract of Kumis Kucing (Orthosiphon stamineus) leaves against Propionibacterium acnes has inhibitory at a concentration of 50% but has not bactericidal.

References

Almatar, Manaf, Rahmat, & Zaidah. (2014). Identifying the Developmental Stages and Optimizing the Sample Preparation for Anatomical Study of Orthosiphon stamineus. Journal of Applied Pharmaceutical Science.
http://www.japsonline.com. doi: 10.7324/JAPS.2014.40314
Alwahid, A., Yusoff, W., Md. Nor, N. S., & Ibrahim, N. (2015). Cytotoxicity and Phytochemical Analyses of Orthosiphon Stamineus Leaves and Flower Extracts. American Institute of Physics, 3.
Anugrah, G. F., Yasa, I. N., & Sujana. (2019). Analisis Perbedaan Dasar Perhitungan Tarif Harga Air Utama.
Anuzar, C., Hazar, S., & Suwendar. (2017). Aktivitas Antibakteri Ekstrak Etanol Daun Cabe Rawit (Capsicum frustescens L.) terhadap Pertumbuhan Bakteri Penyebab Jerawat Propionibacterium Acnes secara In-vitro. Jurnal Farmasi, 457-464.
Asbullah, Wulandari, P., & Febrianita, Y. (2021). Faktor-Faktor yang mempengaruhi terhadap timbulnya Acnes Vulgaris (Jerawat) pada Remaja di SMAN 1 Pelangiran Kabupaten Indragiri Hilir Tahun 2018. Jurnal Keperawatn Abdurrab, 79-88.
Dalimartha, S. (2006). Atlas Tanaman Obat Indonesia Jilid 4. Jakarta: Puspa Swara.
Depkes RI. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Departemen Kesehatan Republik Indonesia.
Dewi, R., Febriani, A., & Wenas, D. M. (2019). Uji Aktivitas Antimikroba Ekstrak Metanol Daun Sirih (Piper betle L.) terhadap Pertumbuhan Bakteri Propionibacterium acnes dan Khamir Malasezia furfur. Jurnal Ilmu Kefarmasian: Sainstech Farma, 32-38.
Dirjen , P. (2014). Farmakope Indonesia Edisi V. Jakarta: Departemen Kesehatan Republik Indonesia.
Fitri, N., Suwendar, & Hazar, S. (2018). Uji Aktivitas Antibakteri Ekstrak Etanol Herba Seledri (Apium Graveolens L.) terhadap Bakteri Propionibacterium Acnes secara In-Vitro. Jurnal Farmasi, 62-67.

Illing, L., Wulan, S., & Erfiana. (2017). Fitokimia Ekstrak Buah Dengen. Jurnal Dinamika, Vol. 8 (1).
Indarto, Narulita, W., Anggoro, B., & Novitasari, A. (2019). Aktivitas Antibakteri Ekstrak Daun Binahong terhadap Propionibacterium Acnes. Biosfer: Jurnal Tadris Biologi Vol. 10 No.1, 67-78.
Jawetz, Melnick, & Adelberg's. (2004). Mikrobiologi Kedokteran. Jakarta: Buku Kedokteran EGC.
Mahdiyah, D., Farida, H., Riwanto, L., Mustofa, M., Wahjono, H., Laksamana, N., & Reki, W. (2020). Screening Of Indonesian Peat Soil Bacteria Producing Antimicrobial Compounds. Saudi Jurnal og Biological Sciences. doi: 10.1016/j.sjbs.2020.05.033.
Mahmudah, Lestari, F., & Atun, S. (2017). Uji Aktivitas Antibakteri Dari Ekstrak Etanol Temukunci (Boesenbergia Pandurata) Terhadap Bakteri Streptococcus Mutans. 37-39.
Mailuhu, M., Max, R., & HarryS. J. (2017). Skrining Fitokimia dan Aktivitas Antioksidan Ekstrak Metanol Kulit Batang Soyogik (Saurauia bracteosa DC. Chem prog, Vol. 1 (10).
Marfu'ah, N., Ramadhan, C., & Hasanah, A. (2019). Uji Efektivitas Ekstrak Etanol Daun Bidara (Ziziphus spina christi L.) terhadap Pertumbuhan Propionibacterim acnes. Pharmasipha, Vol. 3 No. 1.
Marliana, Sartini, & Karim, A. (2018). Efektivitas Beberapa Produk Pembersih Wajah Antiacne terhadap Bakteri Penyebab Jerawat Propionibacterium acnes. Jurnal Biologi Lingkungan, Imdustri Kesehatan, 31-41.
Nair, A., Kiruthika, D., Dheeba, B., & Tilton, F. (2014). Cytotoxic Potensials of Extracts Against Pathogenic Bacteria and Colon Cancer Cells. Asian Journal of Science and Technology, 221-225.
Pratiwi, S. T. (2008). Mikrobiologi Farmasi. Yogyakarta: Erlangga.
Rambikko, S., Fatimawali, & Widdhi, B. (2016). Uji Sensitivitas Bakteri Penyebab Infeksi Nosokimial Saluran Kemih Akibat Penggunaan Kateter Terhadap Antibiotik Ampicillin, Amoxicillin dan Ciprofloxacin di RSUP Prof. Dr. R. D Kandou Manado. PHARMACON Jurnal Ilmiah Farmasi, Vol. 5 (1).
Rollando. (2019). Senyawa Antibakteri dari Fungi Endofit. Seribu Bintang.
Sa'adah, H., Supomo, & Musaenah. (2020). Aktivitas Antibakteri Ekstrak Air Kulit Bawang Merah (Allium cepa L) Terhadap Bakteri Propionibacterium acnes. Jurnal Riset Kefarmasian Indonesia.
Saryono. (2011). Metodologi Penelitian Kesehatan: Penuntun Praktis Bagi Pemula. Mitra Cendikia Press.
Sivakumar, C., & Jeganathan, K. (2018). Phytochemical Profiling of Cat Whisker's (Orthosiphon Stamineus) Tea Leaves Extract. Journal of Pharmacognosy and Phytochemistry, 1396.
Surahmida, & Umarudin. (2019). Studi Fitokimia Ekstrak Daun Kemangi dan Daun Kumis Kucing Menggunakan Pelarut Metanol. Indonesian Chemistry and Application Journal, Vol 3. No. 1.
Susanty, & Bachdim, F. (2016). Perbandingan Metode Ekstraksi Maserasi dan Refluks terhadap Kadar Fenolik dari Ekstrak Tongkol Jagung (Zea mays L.). Konversi Vol. 5 No. 2, 87-93.
Vania, V., Yessie, K., Christel, N., & Reky, R. (2020). Uji Aktivitas Antibakteri Ekstrak Etanol Kulit Buah Pepaya (Carica papaya L.) terhadap Bakteri Penyebab Jerawat Propionibacterium acnes. Jurnal Biofarmasetikal Tropis, 112-121.
Wahyuni, R., Guswandi, & Rivai, H. (2014). Pengaruh Cara Pengeringan Dengan Oven, Kring Angin dan Cahaya Matahari Langsung Terhadap Mutu Simplisia Herba Sambiloto. Jurnal Farmasi Higea.
Widiyanto. (2013). Statistika Terapan: Konsep dan Aplikasi SPSS dalam Penelitian Bidang Pendidikan, Psikologi dan Ilmu Sosial Budaya Lainnya. Jakarta: PT. Elex Media Kompoutindo.
Wijaya, D., Jessy, E., Paendoga, & Jemmy, A. (2014). Skrining Fitokimia dan Uji Aktivitas Antioksidan Dari Daun Nasi (Phrynium capitatum) Dengan Metode DPPH (1,1-difenil-2-pikrilhidrazil). Jurnal , Vol. 3(1).
William, D., Timothy, G., Dirk, M., & Isaac, N. (2016). Andrew's Disease of the skin. Philadelphia, 225-227.
Yunus, I., Widdhi, B., & Edwin, D. (2018). Skrining Fitokimia dan Uji Toksisitas Ekstrak Etanol Daun Langsat (Lansium domesticun Corr) Terhadap Larva Artemia Salina Leasch Dengan Metode Brine Shrimp Lethality Test (BSLT). PHARMACON Jurnal Ilmiah Farmasi, Vol.7 (3).
Zahrah, H., Mustika, A., & Debora, K. (2018). Aktivitas Antibakteri dan Perubahan Morfologi dari Propionibacterium Acnes setelah Pemberian Ekstrak Curcuma Xanthorrhiza. Jurnal Biosains Pasca Sarjana, 1-10. doi: http://dx.doi.org/10.20473.
Zaluchu, S. E. (2020). Strategi Penelitian Kualitatif dan Kuantitatif di Dalam Penelitian Agama. Evangelikal: Jurnal Teologi Injili dan Pembinaan Warga.

Downloads

Published

2021-10-22