S Supportive Therapy for Children with Major Thalassemia: Literature Review
Terapi Suportif Pada Anak Yang Mengalami Thalasemia Mayor : Literature Review
DOI:
https://doi.org/10.33859/pwjn9f73Keywords:
Iron calcium, , growth of thalassemia children, , nutritional supplements, , supportive therapy, thalassemia, thalassemia majorAbstract
Background: Thalassemia is one of the hemolytic anemia diseases genetically from parents to children who are inherited recessively, clinically divided into major and minor thalassemia. The incidence of thalassemia is still high, according to the World Health Organization (WHO) 2018, Almost (7%) of the world's population has the thalassemia gene and in Asia itself the highest incidence is up to (40%). In Indonesia itself, almost every birth of 3,000 babies has thalassemia, and supported by the Indonesian thalassemia foundation in the year (2012) 4,896 rose to 9,028 in the year (2018).
Purpose: This study aims to analyze supportive therapy in children who experience thalassemia major using Literature Review.
Methods: The assessment in this study used The JBI Critical Appraisal Tools to assess the risk of bias in studies with three databases (Googel scholar, DOAJ, and Pubmed) so that the final results obtained 11 articles to be used as a literature review ready for analysis.
Results: This study found a relationship in the application of supportive therapy in children with thalassemia where gene therapy in thalassemia children is very effective in managing dependence on blood transfusions and consumption of iron-calcium therapy. Furthermore, there is a significant relationship between adherence to iron calorie consumption after blood transfusion with the growth of thalassemia children, then the application of nutritional food supplements in the form of vitamin E shows that protein intake and vitamin E intake are associated with hemoglobin levels in children with thalassemia.
Conclusion: The provision of supportive therapy in thalassemia children has a significant relationship in the provision of therapy so that the role of parents is also able to provide treatment with alternative good treatment options so that it can be applied to children who experience thalassemia.
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