E Efek Hipotiroid Subklinis Terhadap Berat Badan Dan Konsumsi Pakan Pada Tikus Jantan Galur Wistar

Efek Hipotiroid Subklinis Terhadap Berat Badan Dan Konsumsi Pakan Pada Tikus Jantan Galur Wistar

Abstract

Hypothyroidism causes weight gain that drives the hypophagia. However, changes in body weight on thyroid hormones within the physiological range and the effect of hypothalamic-pituitary thyroid (HPT) axis in the hypothalamic regulation of appetite is debated. The present study was to observe the effect of of subclinical hyperthyroidism on the BW and food intake of male Wistar rats. Twelve adult male Wistar rats of 200-250 g were devided into 2 groups. One groups were orally administered with KIO3 dose 158,4 μgI/day for 12 weeks and 1 group as the control groups. Food intake were observed daily and rats were weighed every week. Serum TSH and FT4 levels were performed at the end of experiment. Results. There was no significant difference between BW of Subclinical Hypothyroid groups (236,60 ± 6,55 g) and controls (234,43 ± 16,47 g) (p>0,05), food intake of Subclinical Hypothyroid groups (17.35 ± 1,07 g) was significantly (p<0.05) lower than controls (19,73 ± 1,21 g) (p<0,05). The serum TSH levels significantly negatively correlated with food intake (r=-0,702; p<0.05) Subclinical Hypothyroidism induced decreases in food intake of male Wistar rats. Higher in TSH level was correlated with decreases in food intake.